Micronuclei as A Biomarker in Monitoring Genetic Damage in Down Syndrome
نویسندگان
چکیده
Background: Down syndrome (DS) is a most common cause of mental retardation in humans. Monitoring genetic damage in DS individuals helps in evaluating genetic damage. Micronucleus assay is potentially an excellent tool to serve as a biomarker which detects chromosomal loss or malfunction. Aim of the study: The objective of the study is to evaluate micronuclei (MN) frequency in exfoliated buccal cells in DS individuals. Materials and Methods: The study subjects consisted of clinically diagnosed cases of Down syndrome. Healthy subjects without any medical conditions formed the control group. The cyto-smears were stained with Papanicolaou stain. Results and Conclusion: The presence of increased number of micronuclei in Down syndrome (P<0.05) patients may be useful in identifying individuals with increase risk of mental retardation.
منابع مشابه
Biological monitoring of genotoxicity to organophosphate pesticide exposure among rice farmers: Exposure-effect continuum study
Background: This study has used biomarker of exposure-effect continuum to examine the biological characteristics of organophosphate (OP) toxicity and its genotoxic effect among rice farmers. Materials and Methods: A cross-sectional study was conducted among 160 pesticide exposed rice farmers and 160 adults from the fishing village as the unexposed group. They share the common socio-economical ...
متن کامل[Micronuclei and genetic polymorphisms: from exposure to susceptibility].
The concept of genetic susceptibility and interactions between genetic and environmental factors of risk is a new trend in molecular epidemiology studies of cancers. Micronuclei are biomarkers of chromosome damage due to genetic instability or exposure to environmental mutagens or carcinogens. The micronucleus assay in combination with fluorescent in situ hybridization discriminates between mic...
متن کاملInduction of DNA damage, apoptosis and micronuclei in peripheral blood lymphocytes following injection of contrast media in patients with abdominal CT scan
Background: Medical diagnostic procedures such as X-ray and computed Tomography (CT) scan account for considerable percent of patient's exposure to ionizing radiation. The exposure of cells to Ionization radiation results in induction of DNA damage and chromosomal aberrations. Contrast media (CM) are widely used in diagnostic radiology and CT scan. The aim of this study was to study adverse gen...
متن کاملMicronuclei (Oral Cancer Biomarker) Study in Buccal Mucosal Cell with Betel Quid Chewers among Indian Population
Oral cancer is most common cancer in males and third most common in females, the main causative agent being use of chewing betel quid (BQ). The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. Micronuclei (MN) have been proposed as good biomarker to assess cytogenetic damage. MN formation has been observed in c...
متن کاملEvaluation of Chromosomal Aberrations Among Radiotherapy Staff in the City of Tehran Because of Occupational Exposure Using Micronucleus Assay and GTG-Banding
Introduction: Exposure to ionizing radiation as a result of diagnostic, treatment and occupational reasons, has created a remarkable range of cytogenetic damage in the DNA, as the first and main goal of ionizing radiation. The aim of this study is to assess the chromosomal damage in medical radiotherapy workers and its association with effective parameters such as age, sex, duration of employme...
متن کامل